Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

General description

A synthetic peptide that contains the CaM-binding, inhibitory, and autophosphorylation domains of CaM kinase II. Can be phosphorylated at Thr²⁸⁶ by PKC. Useful as a calmodulin binding peptide. Inhibits CaM kinase II (IC₅₀ = 80 nM) by blocking Ca²⁺/calmodulin activation and enzyme active site (IC₅₀ = 2 µM).

A synthetic peptide containing the calmodulin binding site (290-309) and the autophosphorylation site (Thr²⁸⁶) of CaM kinase II. Can be phosphorylated at Thr²⁸⁶ by PKC. Useful as a calmodulin binding peptide. Inhibits CaM kinase II by blocking Ca²⁺/calmodulin activation (IC₅₀ = 80 nM) and enzyme-active site (IC₅₀ = 2 µM).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Waxham, M.N., et al. 1993. Biochemistry32, 2923.Waxham, M.N., et al. 1993. Brain Res. 609, 1.Fukunaga, K., et al. 1990. J. Neurochem.54, 103.Colbran, R.J., et al. 1989. J. Biol. Chem. 264, 4800.Colbran, R.J., et al. 1988. J. Biol. Chem.263, 18145.

Packaging

Yes

500 µg in Plastic ampoule

Sequence

H-Met-His-Arg-Gln-Glu-Thr-Val-Asp-Cys-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH

Warning

Toxicity: Standard Handling (A)